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 Formulary Chapter 8: Malignant disease and immunosuppression - Full Chapter
08.01.03  Expand sub section  Antimetabolites
Cytotoxic Drug Azacitidine (Vidaza®)
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High Cost Medicine
 
Link  NICE TA218: azacitidine for myelodysplastic syndromes
Link  NICE TA399: Azacitidine for treating acute myeloid leukaemia with more than 30% bone marrow blasts
   
Cytotoxic Drug Capecitabine (Xeloda®)
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Red
NHS England

Oral cancer drug (NHSE commissioned)

 
Link  NICE TA100: Colon cancer (adjuvant) - capecitabine and oxaliplatin
Link  NICE TA191: Gastric cancer (advanced) - capecitabine
Link  NICE TA60: Colorectal cancer - capecitabine and tegafur uracil
   
Cytotoxic Drug Cladribine
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Formulary
Red
High Cost Medicine
NHS England

 Consultant haematologist use only. For hairy cell leukaemia

 
Link  NICE TA493: Cladribine tablets for treating relapsing–remitting multiple sclerosis
   
Cytotoxic Drug Cytarabine
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Red
 
   
Cytotoxic Drug Fludarabine Phosphate (Fludara®)
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Red
 
Link  NICE TA119: Leukaemia (lymphocytic) - fludarabine
Link  NICE TA29: Leukaemia (lymphocytic) - fludarabine
   
Cytotoxic Drug Fluorouracil
(Chemotherapy)
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Red
 
   
Cytotoxic Drug Gemcitabine (Gemzar®)
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Red

Prescribing note: Use according to NICE guidance

 
Link  NICE TA116: Breast cancer - gemcitabine
Link  NICE TA25: Pancreatic cancer - gemcitabine
Link  NICE TA389 - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
   
Cytotoxic Drug Mercaptopurine
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Red Amber
NHS England

Inflammatory bowel disease – see shared care 50mg tablets

Oral cancer drug (NHSE commissioned) - RED

Unlicensed doses eg 10mg capsules RED

 

 
   
Cytotoxic Drug Methotrexate
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Red Amber
NHS England

Oral Amber – except when used in cancer regimens when RED hospital only.

Only 2.5mg tablets to be prescribed weekly for non-cancer indications

Injection - Red

 
   
Cytotoxic Drug Pemetrexed (Alimta®)
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High Cost Medicine
Cancer Drugs Fund
 
Link  NICE TA135: Mesothelioma - pemetrexed disodium
Link  NICE TA181: Lung cancer (non-small cell, first line treatment) - pemetrexed
Link  NICE TA190: Lung cancer (non-small-cell) - pemetrexed (maintenance)
Link  NICE TA402: Pemetrexed maintenance treatment for non-squamous non-small-cell lung cancer after pemetrexed and cisplatin
   
Cytotoxic Drug Tioguanine (Lanvis®)
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Red
NHS England

Oral cancer drug (NHSE commissioned)

 

 
   
 ....
 Non Formulary Items
Cladribine  (Litak®)

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Non Formulary
 
Cytotoxic Drug  Clofarabine  (Evoltra®)

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Non Formulary
High Cost Medicine
Cancer Drugs Fund
 
Cytarabine  (DepoCyte®)

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Non Formulary
 
Cytotoxic Drug  Decitabine  (Dacogen®)

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Non Formulary
High Cost Medicine
Link  NICE TA270: Leukaemia (acute myeloid ) - decitabine (terminated appraisal)
 
Nelarabine  (Atriance®)

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Non Formulary
High Cost Medicine
Cancer Drugs Fund
 
Cytotoxic Drug  Raltitrexed  (Tomudex®)

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Non Formulary
 
Cytotoxic Drug  Tegafur with Uracil  (Uftoral®)

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Non Formulary
Link  NICE TA61: Capcitabine and tegafur - Colorectal cancer
 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
SMC
Scottish Medicines Consortium
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG

Traffic Light Status Information

Status Description

Green

Suitable for use in primary care  

Amber

Specialist initiation. Shared care in place  

Red

Red do not use..  

Advice

Some formulations restricted  

Black

NICE "Do not do"  

Green 1

1st line option  

Green 2

2nd line option  

Green 3

3rd line option only  

Not Recomended / Black

Low Value Medicine not recommended for use - see NHSE guidelines  

OTC

This preparation should be bought over the counter for self-care  

Red Amber

Check product description for traffic light status  

Red Black

Low Value Medicine  

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