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Wye Valley NHS Trust
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 Formulary Chapter 8: Malignant disease and immunosuppression - Full Chapter
08.01  Expand sub section  Cytotoxic drugs
08.01  Expand sub section  Side-effects of cytotoxic drugs
08.01  Expand sub section  Drugs for cytotoxic-induced side-effects
Calcium Folinate
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Formulary
Red
NHS England
 
   
Mesna
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Formulary
Red
NHS England

By mouth the dose is given 2 hours before treatment with oxazaphosphorine and repeated at 4 and 6 hours after treatment 

 
   
08.01.01  Expand sub section  Alkylating drugs
Bendamustine
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Formulary
Red
High Cost Medicine
Cancer Drugs Fund
 
Link  NICE TA216: Bendamustine for CLL
   
Cytotoxic Drug Busulfan
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Formulary
Red
NHS England

Oral cancer drug (NHSE commissioned)

 

 
   
Cytotoxic Drug Carmustine
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Formulary
Red

Oral cancer drug commissioned by NHSE

 
Link  NICE TA121: Glioma (newly diagnosed and high grade) - carmustine implants and temozolomide
   
Cytotoxic Drug Chlorambucil
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Formulary
Red
NHS England

Oral cancer drug (NHSE commissioned)

 

 
   
Cytotoxic Drug Cyclophosphamide
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Formulary
Red Amber
NHS England

Oral cancer drug commissioned by NHSE

Amber shared care status if rheumatology

 
   
Estramustine Phosphate (Estracyt®)
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Formulary
Red
NHS England

Oral cancer drug (NHSE commissioned)

 

 
   
Cytotoxic Drug Ifosfamide (Mitoxana®)
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Formulary
Red
NHS England
 
   
Cytotoxic Drug Lomustine
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Formulary
Red
NHS England

Oral cancer drug (NHSE commissioned)

 

 
   
Cytotoxic Drug Melphalan
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Formulary
Red
NHS England

Oral cancer drug (NHSE commissioned)

 

 
   
Thiotepa
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Formulary
Red
NHS England
 
   
Treosulfan
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Formulary
Red

Oral cancer drug (NHSE commissioned)

 
   
08.01.02  Expand sub section  Anthracyclines and other cytotoxic antibiotics to top
Cytotoxic Drug Bleomycin
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Formulary
Red
 
   
Cytotoxic Drug Dactinomycin (Cosmegen Lyovac®)
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Red
NHS England
 
   
Cytotoxic Drug Daunorubicin
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Formulary
Red
 
   
Cytotoxic Drug Doxorubicin
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Formulary
Red
 
   
Cytotoxic Drug Doxorubicin (Caelyx®)
(Liposomal)
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Red
High Cost Medicine
Cancer Drugs Fund
 
Link  NICE TA389 - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
Link  NICE TA440 : Pegylated liposomal irinotecan for treating pancreatic cancer after gemcitabine
   
Cytotoxic Drug Epirubicin
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Formulary
Red
 
   
Cytotoxic Drug Idarubicin (Zavedos®)
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Formulary
Red
NHS England

Oral cancer drug (NHSE commissioned)

 

 
   
Cytotoxic Drug Mitomycin
(injection, bladder)
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Formulary
Red
 
   
Cytotoxic Drug Mitoxantrone
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Formulary
Red
 
   
Cytotoxic Drug Pixantrone
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Formulary
Red
High Cost Medicine
 
Link  NICE TA306: Pixantrone monotherapy
   
08.01.03  Expand sub section  Antimetabolites
Cytotoxic Drug Azacitidine (Vidaza®)
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Formulary
High Cost Medicine
 
Link  NICE TA218: azacitidine for myelodysplastic syndromes
Link  NICE TA399: Azacitidine for treating acute myeloid leukaemia with more than 30% bone marrow blasts
   
Cytotoxic Drug Capecitabine (Xeloda®)
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Formulary
Red
NHS England

Oral cancer drug (NHSE commissioned)

 
Link  NICE TA100: Colon cancer (adjuvant) - capecitabine and oxaliplatin
Link  NICE TA191: Gastric cancer (advanced) - capecitabine
Link  NICE TA60: Colorectal cancer - capecitabine and tegafur uracil
   
Cytotoxic Drug Cladribine
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Formulary
Red
High Cost Medicine
NHS England

 Consultant haematologist use only. For hairy cell leukaemia

 
Link  NICE TA493: Cladribine tablets for treating relapsing–remitting multiple sclerosis
   
Cytotoxic Drug Cytarabine
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Formulary
Red
 
   
Cytotoxic Drug Fludarabine Phosphate (Fludara®)
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Formulary
Red
 
Link  NICE TA119: Leukaemia (lymphocytic) - fludarabine
Link  NICE TA29: Leukaemia (lymphocytic) - fludarabine
   
Cytotoxic Drug Fluorouracil
(Chemotherapy)
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Formulary
Red
 
   
Cytotoxic Drug Gemcitabine (Gemzar®)
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Formulary
Red

Prescribing note: Use according to NICE guidance

 
Link  NICE TA116: Breast cancer - gemcitabine
Link  NICE TA25: Pancreatic cancer - gemcitabine
Link  NICE TA389 - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
   
Cytotoxic Drug Mercaptopurine
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Formulary
Red Amber
NHS England

Inflammatory bowel disease – see shared care 50mg tablets

Oral cancer drug (NHSE commissioned) - RED

Unlicensed doses eg 10mg capsules RED

 

 
   
Cytotoxic Drug Methotrexate
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Formulary
Red Amber
NHS England

Oral Amber – except when used in cancer regimens when RED hospital only.

Only 2.5mg tablets to be prescribed weekly for non-cancer indications

Injection - Red

 
   
Cytotoxic Drug Pemetrexed (Alimta®)
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Formulary
High Cost Medicine
Cancer Drugs Fund
 
Link  NICE TA135: Mesothelioma - pemetrexed disodium
Link  NICE TA181: Lung cancer (non-small cell, first line treatment) - pemetrexed
Link  NICE TA190: Lung cancer (non-small-cell) - pemetrexed (maintenance)
Link  NICE TA402: Pemetrexed maintenance treatment for non-squamous non-small-cell lung cancer after pemetrexed and cisplatin
   
Cytotoxic Drug Tioguanine (Lanvis®)
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Formulary
Red
NHS England

Oral cancer drug (NHSE commissioned)

 

 
   
08.01.04  Expand sub section  Vinca alkaloids and etoposide
Cytotoxic Drug Etoposide
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Red
NHS England

 Vinca alkaloids must never be given intrathecally. This is extremely dangerous! 

 
   
Cytotoxic Drug Vinblastine Sulphate
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Red

Vinca alkaloids must never be given intrathecally. This is extremely dangerous!

 
   
Cytotoxic Drug Vincristine Sulphate
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Formulary
Red

Vinca alkaloids must never be given intrathecally. This is extremely dangerous!

 
   
Cytotoxic Drug Vinorelbine
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Red

Vinca alkaloids must never be given intrathecally. This is extremely dangerous!  

 
   
08.01.05  Expand sub section  Other antineoplastic drugs
Alectinib (Alecensa®)
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Formulary
Red
NHS England

Oral cancer drug NHSE commissioned

 
   
Cabozantinib (Cabometyx®)
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Formulary
Red
High Cost Medicine

Oral cancer drug (NHSE commissioned)

 

 
   
Ceritinib (Zykadia)
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Formulary
Red
High Cost Medicine
NHS England

Oral cancer drug (NHSE commissioned)

 

 
Link  NICE TA395: Ceritinib for previously treated anaplastic lymphoma kinase positive non-small-cell lung cancer
Link  NICE TA500: Ceritinib for untreated ALK-positive non-small-cell lung cancer
   
Ibrutinib (Imbruvica®)
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Formulary
Red
High Cost Medicine
Cancer Drugs Fund
NHS England

Oral cancer drug (NHSE commissioned)

 

 
Link  NICE TA429 : Ibrutinib for previously treated chronic lymphocytic leukaemia and untreated chronic lymphocytic leukaemia with 17p deletion or TP53 mutation
Link  NICE TA491: Ibrutinib for treating Waldenstrom’s macroglobulinaemia
Link  NICE TA502: Ibrutinib for treating relapsed or refractory mantle cell lymphoma
   
Ixazomib (Ninlaro®)
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Formulary
Red
NHS England

Oral cancer drug (NHSE commissioned)

 

 
Link  NICE TA505: Ixazomib with lenalidomide and dexamethasone for treating relapsed or refractory multiple myeloma
   
Lenvatinib (Lenvima®)
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Formulary
Red
NHS England

Oral cancer drug (NHSE commissioned)

 

 
Link  NICE TA498: Lenvatinib with everolimus for previously treated advanced renal cell carcinoma
   
Venetoclax (Venclyxto®)
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Formulary
Red
Cancer Drugs Fund

Oral cancer drug (NHSE commissioned)

 

 
Link  NICE TA487: Venetoclax for treating chronic lymphocytic leukaemia
   
08.01.05  Expand sub section  Amsacrine
08.01.05  Expand sub section  Arsenic trioxide to top
08.01.05  Expand sub section  Bevacizumab
08.01.05  Expand sub section  Bexarotene
08.01.05  Expand sub section  Bortezomib
Cytotoxic Drug Bortezomib (Velcade®)
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Formulary
Red
High Cost Medicine
Cancer Drugs Fund
 
Link  NICE TA129: Multiple myeloma - bortezomib
Link  NICE TA228: 1st line treatment of multiple myeloma
Link  NICE TA311: Bortezomib for induction therapy in multiple myeloma
Link  NICE TA370: Bortezomib for previously untreated mantle cell lymphoma
   
08.01.05  Expand sub section  Brentuximab vedotin
08.01.05  Expand sub section  Cetuximab to top
08.01.05  Expand sub section  Crisantaspase
08.01.05  Expand sub section  Dacarbazine and Temozolomide
Cytotoxic Drug Dacarbazine
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Restricted Drug Restricted
Red
 
   
Cytotoxic Drug Temozolomide (Temodal®)
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Restricted Drug Restricted
Red
High Cost Medicine
 
Link  NICE TA121: Glioma (newly diagnosed and high grade)
Link  NICE TA23: Guidance on the use of temozolomide for the treatment of recurrent malignant glioma (brain cancer)
   
08.01.05  Expand sub section  Erlotinib
Erlotinib (Tarceva® )
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Restricted Drug Restricted
Red
High Cost Medicine
NHS England

Oral cancer drug (NHSE commissioned)

 

 
Link  NICE TA227: Lung cancer (non-small-cell) maintenance - erlotinib
Link  NICE TA258: Lung cancer (non-small-cell) 1st line- erlotinib
Link  NICE TA374: Erlotinib and gefitinib for treating non-small-cell lung cancer that has progressed after prior chemotherapy
   
08.01.05  Expand sub section  Hydroxycarbamide
Cytotoxic Drug Hydroxycarbamide
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Restricted Drug Restricted
Amber

Haematology - see shared care

 

 
Link  Shared Care
   
08.01.05  Expand sub section  Imatinab to top
08.01.05  Expand sub section  Ipilimumab
08.01.05  Expand sub section  Mitotane
08.01.05  Expand sub section  Panitumumab
08.01.05  Expand sub section  Pentostatin
08.01.05  Expand sub section  Platinum compounds to top
Cytotoxic Drug Carboplatin
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Restricted Drug Restricted
Red
 
   
Carboplatin (Paraplatin®)
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Restricted Drug Restricted
Red
 
   
Cytotoxic Drug Cisplatin
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Restricted Drug Restricted
Red
 
   
Cytotoxic Drug Oxaliplatin
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Restricted Drug Restricted
Red

To be used in accordance with NICE guidance

 
Link  NICE TA100: Colon cancer (adjuvant) - capecitabine and oxaliplatin
   
Oxaliplatin (Eloxatin®)
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Restricted Drug Restricted
Red

To be used in accordance with NICE guidance

 
   
08.01.05  Expand sub section  Porfimer sodium and temoporfin
08.01.05  Expand sub section  Procarbazine
Cytotoxic Drug Procarbazine
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Restricted Drug Restricted
Red

Oral cancer drug (NHSE commissioned)

 

 
   
08.01.05  Expand sub section  Protein kinase inhibitors
Cabozantinib (Cometriq®)
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Restricted Drug Restricted
Red
Cancer Drugs Fund

Oral cancer drug (NHSE commissioned)

 

 
Link  NICE TA463 : Cabozantinib for previously treated advanced renal cell carcinoma
Link  NICE TA516: Cabozantinib for treating medullary thyroid cancer
   
Dasatinib (Sprycel®)
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Restricted Drug Restricted
Red
High Cost Medicine
Cancer Drugs Fund
NHS England

Oral cancer drug (NHSE commissioned)

 

 
Link  NICE TA241: CML where treatment with imatinib has failed
Link  NICE TA425: Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
Link  NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
   
Erlotinib (Tarceva®)
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Restricted Drug Restricted
Red
NHS England

Oral cancer drug (NHSE commissioned)

 

 
   
Gefitinib (Iressa®)
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Restricted Drug Restricted
Red
High Cost Medicine
NHS England

Oral cancer drug (NHSE commissioned)

 
Link  NICE TA192: Lung cancer (non-small-cell, first line) - gefitinib
Link  NICE TA374: Erlotinib and gefitinib for treating non-small-cell lung cancer that has progressed after prior chemotherapy
   
Cytotoxic Drug Imatinib (Gilvec®)
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Restricted Drug Restricted
Red
High Cost Medicine
NHS England

 Restricted: NICE approved for CML (philidephia chromosome + ve)

 
   
Nilotinib (Tasigna®)
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Restricted Drug Restricted
Red
High Cost Medicine

Oral cancer drug (NHSE commissioned)

 

 
Link  NICE TA241: Dasatinib, nilotinib and high dose imatinib for CML
Link  NICE TA251: Dasatinib, nilotinib and imatinib for first line treatment of CML
Link  NICE TA425: Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
Link  NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
   
Regorafenib (Stivarga® )
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Restricted Drug Restricted
Red
High Cost Medicine
Cancer Drugs Fund
 
Link  NICE TA488: Regorafenib for previously treated unresectable or metastatic gastrointestinal stromal tumours
Link  NICE TA514: Regorafenib for previously treated advanced hepatocellular carcinoma
   
Sorafenib (Nexavar®)
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Restricted Drug Restricted
Red
High Cost Medicine
Cancer Drugs Fund

Oral cancer drug NHSE commissioned

 
Link  NICE TA474: Sorafenib for treating advanced hepatocellular carcinoma
   
Sunitinib (Sutent®)
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Restricted Drug Restricted
Red
High Cost Medicine
Cancer Drugs Fund

Oral cancer drug (NHSE commissioned)

 
Link  NICE TA169: Renal cell carcinoma - sunitinib
Link  NICE TA179: Gastrointestinal stromal tumours - sunitinib
Link  NICE TA449 : Everolimus and sunitinib for treating unresectable or metastatic neuroendocrine tumours in people with progressive disease
   
Tivozanib
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Restricted Drug Restricted
Red

Oral cancer drug (NHSE commissioned)

 
Link  NICE TA512: Tivozanib for treating advanced renal cell carcinoma
   
08.01.05  Expand sub section  Taxanes
Cytotoxic Drug Docetaxel (Taxotere®)
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Restricted Drug Restricted
Red
 
Link  NICE TA101: Prostate cancer (hormone-refractory) - docetaxel
Link  NICE TA109: Breast cancer (early) - docetaxel
   
Cytotoxic Drug Paclitaxel
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Restricted Drug Restricted
Red
 
Link  NICE TA108: Breast cancer (early) - paclitaxel
Link  NICE TA389 - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
Link  NICE TA476: Paclitaxel as albumin-bound nanoparticles with gemcitabine for untreated metastatic pancreatic cancer
   
Paclitaxel (Abraxane®)
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Restricted Drug Restricted
Red
 
   
Paclitaxel (Taxol®)
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Restricted Drug Restricted
Red
 
   
08.01.05  Expand sub section  Topoisomerase I inhibitors to top
Cytotoxic Drug Irinotecan Hydrochloride
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Restricted Drug Restricted
Red
 
   
08.01.05  Expand sub section  Trabectedin
08.01.05  Expand sub section  Trastuzumab
Cytotoxic Drug Trastuzumab (Herceptin®)
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Restricted Drug Restricted
Red

Herceptin® – to be used in accordance with NICE guidance

 
Link  NICE TA208: Gastric cancer (HER2-positive metastatic) - trastuzumab
Link  NICE TA257: in combination with an aromatase inhibitor for HER2 positive metastatic breast cancer
Link  NICE TA34: Breast cancer - trastuzumab
   
08.01.05  Expand sub section  Tretinoin
08.01.05  Expand sub section  Vismodegib
 ....
 Non Formulary Items
Afatinib  (Giotrif®)

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Non Formulary
Link  NICE TA310: Afatinib for treating epidermal growth factor receptor mutation-positive locally advanced or metastatic non-small-cell lung cancer
 
Cytotoxic Drug  Aflibercept  (Zaltrap®)

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Non Formulary
High Cost Medicine
Cancer Drugs Fund
Link  NICE TA307: Aflibercept in combination with irinotecan and fluorouracil-based therapy for treating metastatic colorectal cancer that has progressed following prior oxaliplatin-based chemotherapy
 
Amifostine  (Ethyol®)

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Non Formulary
 
Cytotoxic Drug  Amsacrine  (Amsidine®)

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Non Formulary
 
Anamorelin

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Non Formulary
 
Anamorelin

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Non Formulary
 
Cytotoxic Drug  Arsenic Trioxide  (Trisenox®)

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Non Formulary
Link  NICE TA526: Arsenic trioxide for treating acute promyelocytic leukaemia
 
Atezolizumab  (Tecentriq®)

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Non Formulary
High Cost Medicine
Cancer Drugs Fund
Link  NICE TA492: Atezolizumab for untreated locally advanced or metastatic urothelial cancer when cisplatin is unsuitable
Link  NICE TA520 : Atezolizumab for treating locally advanced or metastatic non-small-cell lung cancer after chemotherapy
Link  NICE TA525: Atezolizumab for treating locally advanced or metastatic urothelial carcinoma after platinum-containing chemotherapy
 
Avelumab

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Non Formulary
Link  NICE TA517: Avelumab for treating metastatic Merkel cell carcinoma
 
Axitinib  (Inlyta®)

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Non Formulary
High Cost Medicine
Link  NICE TA333: Axitinib for advanced renal cell carcinoma
 
Begelomab  (Begedina®)

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Non Formulary
 
Bevacizumab  (Avastin®)
(Oncology)

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Non Formulary
High Cost Medicine
Cancer Drugs Fund
Link  NICE TA214: Breast Cancer with taxane
Link  NICE TA263: Breast cancer with capecitabine
Link  NICE TA285: Ovarian, fallopian tube and primary peritoneal cancer (recurrent advanced, platinum-sensitive or partially platinum-sensitive) - bevacizumab
 
Bexarotene  (Targretin®)

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Non Formulary
 
Bosutinib  (Bosulif®)

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Non Formulary
High Cost Medicine
Cancer Drugs Fund
Link  NICE TA401: Bosutinib for previously treated chronic myeloid leukaemia
 
Brentuximab vedotin  (Adcetris®)

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Non Formulary
High Cost Medicine
Cancer Drugs Fund
Link  NICE TA446 : Brentuximab vedotin for treating CD30-positive Hodgkin lymphoma
Link  NICE TA478L Brentuximab vedotin for treating relapsed or refractory systemic anaplastic large cell lymphoma
Link  NICE TA524: Brentuximab vedotin for treating CD30-positive Hodgkin lymphoma
 
Cytotoxic Drug  Cabazitaxel  (Jevtana®)

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Non Formulary
High Cost Medicine
Link  NICE TA391: Cabazitaxel for hormone-relapsed metastatic prostate cancer treated with docetaxel
 
Calcium Leofolinate  (Isovorin®)

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Non Formulary
 
Carfilzomib  (Kyprolis®)

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Non Formulary
Link  NICE TA457 : Carfilzomib for previously treated multiple myeloma
 
Cetuximab  (Erbitux®)

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Non Formulary
High Cost Medicine
Cancer Drugs Fund
Link  NICE TA145: Head and neck cancer - cetuximab
Link  NICE TA176: Colorectal cancer (first line) - cetuximab
Link  NICE TA439 : Cetuximab and panitumumab for previously untreated metastatic colorectal cancer
Link  NICE TA473: Cetuximab for treating recurrent or metastatic squamous cell cancer of the head and neck
 
Cladribine  (Litak®)

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Non Formulary
 
Cytotoxic Drug  Clofarabine  (Evoltra®)

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Non Formulary
High Cost Medicine
Cancer Drugs Fund
 
Crisantaspase  (Erwinase®)

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Non Formulary
 
Crizotinib  (Xalkori®)

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Non Formulary
High Cost Medicine
Cancer Drugs Fund
Link  NICE TA406: Crizotinib for untreated anaplastic lymphoma kinase-positive advanced non-small-cell lung cancer
Link  NICE TA422: Crizotinib for previously treated anaplastic lymphoma kinase-positive advanced non-small-cell lung cance
Link  NICE TA529: Crizotinib for treating ROS1-positive advanced non-small-cell lung cancer
 
Cytarabine  (DepoCyte®)

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Non Formulary
 
Dabrafenib  (Tafinlar®)

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Non Formulary
High Cost Medicine
Cancer Drugs Fund
Link  NICE TA321:Dabrafenib for BRAF V600 +ve melanoma
Link  NICE TA396:Trametinib in combination with dabrafenib for treating unresectable or metastatic melanoma
 
Daratumumab  (Darzalex®)

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Non Formulary
High Cost Medicine
Link  NICE TA510: Daratumumab monotherapy for treating relapsed and refractory multiple myeloma
 
Cytotoxic Drug  Decitabine  (Dacogen®)

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Non Formulary
High Cost Medicine
Link  NICE TA270: Leukaemia (acute myeloid ) - decitabine (terminated appraisal)
 
Dexrazoxane  (Savene®)

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Non Formulary
Red
High Cost Medicine

For anthracycline extravasation. The first dose should be given as soon as possible and within six hours after the injury

Dose by intravenous infusion 1g/m² (maximum 2g) for two days then 500mg/m² for one day. Local coolants such as ice packs should be removed at least 15 minutes before administration.

Usage to be reported to Andy Hedges ext. 2997

 
Disodium Folinate  (Sodiofolin®)

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Non Formulary
 
Disodium Levofolinate
(Lvofolinic acid )

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Non Formulary
 
Elotuzumab  (Empliciti®)

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Non Formulary
 
Cytotoxic Drug  Eribulin  (Halaven®)

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Non Formulary
High Cost Medicine
Cancer Drugs Fund
Link  NICE TA423: Eribulin for treating locally advanced or metastatic breast cancer after 2 or more chemotherapy regimens
Link  NICE TA515: Eribulin for treating locally advanced or metastatic breast cancer after 1 chemotherapy regimen
 
Everolimus  (Afinitor®)

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Non Formulary
High Cost Medicine
Cancer Drugs Fund
Link  NICE TA348: Preventing Rejection in Liver Transplant
Link  NICE TA421: Everolimus with exemestane for treating advanced breast cancer after endocrine therapy
Link  NICE TA449 : Everolimus and sunitinib for treating unresectable or metastatic neuroendocrine tumours in people with progressive disease
 
Everolimus  (Votubia®)

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Non Formulary
High Cost Medicine
Link  NICE TA449 : Everolimus and sunitinib for treating unresectable or metastatic neuroendocrine tumours in people with progressive disease
 
Idelalisib  (Zydelig®)

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Non Formulary
Link  NICE TA359: Chronic lymphocytic leukaemia - Idelalisib
 
Ipilimumab  (Yervoy®)

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Non Formulary
High Cost Medicine
Cancer Drugs Fund
Link  NICE TA268: Ipilimumab for previously treated advanced (unresectable or metastatic) melanoma
Link  NICE TA319: Ipilimumab for previously untreated advanced (unresectable or metastatic) melanoma
Link  NICE TA400: Nivolumab in combination with ipilimumab for treating advanced melanoma
 
Cytotoxic Drug  Irinotecan hydrochloride trihydrate  (Onivyde®)
(pegylated liposomal)

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Non Formulary
 
Lapatinib  (Tyverb®)

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Non Formulary
High Cost Medicine
Link  NICE TA257: in combination with an aromatase inhibitor for HER2 positive metastatic breast cancer
 
Midostaurin

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Non Formulary
Link  NICE TA523: Midostaurin for untreated acute myeloid leukaemia
 
Mitotane  (Lysodren®)

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Non Formulary
 
Necitumumab  (Portrazza®)

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Non Formulary
High Cost Medicine
Link  NICE TA411: Necitumumab for untreated advanced or metastatic squamous non-small-cell lung cancer
 
Nelarabine  (Atriance®)

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Non Formulary
High Cost Medicine
Cancer Drugs Fund
 
Olaratumab  (Lartruvo®)

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Non Formulary
High Cost Medicine
 
Pablociclib  (Ibrance®)

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Non Formulary
 
Cytotoxic Drug  Paclitaxel - Albumin Bound Formulation  (Abraxane®)

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Non Formulary
High Cost Medicine
Link  NICE TA360: Pancreatic cancer - paclitaxel with gemcitabine
 
Palifermin  (Kepivance®)

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Non Formulary
 
Cytotoxic Drug  Panitumumab  (Vectibix®)

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Non Formulary
High Cost Medicine
Cancer Drugs Fund
Link  NICE TA439 : Cetuximab and panitumumab for previously untreated metastatic colorectal cancer
 
Cytotoxic Drug  Panobinostat  (Farydak®)

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Non Formulary
High Cost Medicine
Link  NICE TA380: Panobinostat for treating multiple myeloma after at least 2 previous treatments
 
Pazopanib  (Votrient®)

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Non Formulary
High Cost Medicine
Link  NICE TA215: Pazopanib in renal cell cancer
 
Pegaspargase  (Oncaspar®)

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Non Formulary
Link  NICE TA408: Pegaspargase for treating acute lymphoblastic leukaemia
 
Pembrolizumab  (Keytruda®)

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Non Formulary
High Cost Medicine
Link  NICE TA357: Pembrolizumab for melanoma after ipilimumab
Link  NICE TA366: Pembrolizumab for advanced melanoma not previously treated with ipilimumab
Link  NICE TA428: Pembrolizumab for treating PD-L1-positive non-small-cell lung cancer after chemotherapy
Link  NICE TA447 : Pembrolizumab for untreated PD-L1-positive metastatic non-small-cell lung cancer
Link  NICE TA519: Pembrolizumab for treating locally advanced or metastatic urothelial carcinoma after platinum-containing chemotherapy
Link  NICE TA522: Pembrolizumab for untreated locally advanced or metastatic urothelial cancer when cisplatin is unsuitable
 
Cytotoxic Drug  Pentostatin  (Nipent®)

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Non Formulary
 
Cytotoxic Drug  Pertuzumab  (Perjeta®)

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Non Formulary
High Cost Medicine
Cancer Drugs Fund
Link  NICE TA424: Pertuzumab for the neoadjuvant treatment of HER2-positive breast cancer
Link  NICE TA509: Pertuzumab with trastuzumab and docetaxel for treating HER2-positive breast cancer
 
Ponatinib  (Iclusig®)

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Non Formulary
High Cost Medicine
Cancer Drugs Fund
Link  NICE TA451 : Ponatinib for treating chronic myeloid leukaemia and acute lymphoblastic leukaemia
 
Porfimer Sodium  (Photofrin ®)

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Non Formulary
 
Cytotoxic Drug  Raltitrexed  (Tomudex®)

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Non Formulary
 
Ramucirumab  (Cyramza®)

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Non Formulary
High Cost Medicine
Link  NICE TA403: Ramucirumab for previously treated locally advanced or metastatic non-small-cell lung cancer
 
Rociletinib

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Non Formulary
 
Ruxolitinib  (Jakavi®)

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Non Formulary
High Cost Medicine
Link  NICE TA386: Ruxolitinib for treating disease-related splenomegaly or symptoms in adults with myelofibrosis
 
Sonidegib  (Odomzo®)

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Non Formulary
 
Cytotoxic Drug  Talimogene laherparepvec  (Imlygic®)

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Non Formulary
Link  NICE TA410: Talimogene laherparepvec for treating unresectable metastatic melanoma
 
Cytotoxic Drug  Tegafur with Uracil  (Uftoral®)

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Non Formulary
Link  NICE TA61: Capcitabine and tegafur - Colorectal cancer
 
Temoporfin  (Foscan®)

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Non Formulary
 
Cytotoxic Drug  Temsirolimus  (Torisel®)

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Non Formulary
High Cost Medicine
Cancer Drugs Fund
 
Cytotoxic Drug  Topotecan  (Hycamtin®)

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Non Formulary
Link  NICE TA183: Cervical cancer (recurrent) - topotecan
Link  NICE TA184: Lung cancer (small-cell) - topotecan
Link  NICE TA389 - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
 
Cytotoxic Drug  Trabectedin  (Yondelis®)

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Non Formulary
Link  NICE TA185: Soft tissue sarcoma - trabectedin
Link  NICE TA389 - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
 
Trametinib  (Mekinist®)

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Non Formulary
High Cost Medicine
Cancer Drugs Fund
Link  NICE TA396: Trametinib in combination with dabrafenib for treating unresectable or metastatic melanoma
 
Cytotoxic Drug  Trastuzumab emtansine  (Kadcyla®)

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Non Formulary
Cancer Drugs Fund
Link  NICE TA458 : Trastuzumab emtansine for treating HER2-positive advanced breast cancer after trastuzumab and a taxan
 
Tretinoin  (Vesanoid®)

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Non Formulary
 
Trifluridine-tipiracil  (Lonsurf®)

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Non Formulary
High Cost Medicine
 
Cytotoxic Drug  Vandetanib  (Caprelsa®)

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Non Formulary
High Cost Medicine
Cancer Drugs Fund
 
Vemurafenib  (Zelboraf®)

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Non Formulary
High Cost Medicine
Link  NICE TA269: Vemurafenib for treating malignant melanoma
 
Cytotoxic Drug  Vindesine Sulphate  (Eldisine®)

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Non Formulary
 
Cytotoxic Drug  Vinflunine  (Javlor®)

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Non Formulary
Link  NICE TA272: Urothelial tract carcinoma (transitional cell, advanced, metastatic) - vinflunine
 
Cytotoxic Drug  Vismodegib  (Erivedge®)

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Non Formulary
High Cost Medicine
Cancer Drugs Fund
Link  NICE TA489: Vismodegib for treating basal cell carcinoma
 
Vosaroxin  (Qinprezo)

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Non Formulary
High Cost Medicine
 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
SMC
Scottish Medicines Consortium
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG

Traffic Light Status Information

Status Description

Green

Suitable for use in primary care  

Amber

Specialist initiation. Shared care in place  

Red

Red do not use..  

Advice

Some formulations restricted  

Black

NICE "Do not do"  

Green 1

1st line option  

Green 2

2nd line option  

Green 3

3rd line option only  

Not Recomended / Black

Low Value Medicine not recommended for use - see NHSE guidelines  

OTC

This preparation should be bought over the counter for self-care  

Red Amber

Check product description for traffic light status  

Red Black

Low Value Medicine  

netFormulary